Original

El Azzouzi, K., Wiesner, C., Linder, S. (2016)
Metalloproteinase MT1-MMP islets act as memory devices for podosome reemergence.
J. Cell Biol. 213, 109-125
Comment in: Gucciardo, E., Mobashir, M., Lehti, K. (2016). Proactive for invasion: Reuse of matrix metalloproteinase for structural memory. J. Cell Biol. 213, 11-13
UKE „paper of the month“ June 2016

Panzer L, Trübe L, Klose M, Joosten B, Slotman J, Cambi A, Linder S. (2016)
The formins FHOD1 and INF2 regulate inter- and intra- structural contractility of podosomes.
J Cell Sci. 2016 Jan 15;129(2):298-313
highlighted in the „In this Issue“ section of J. Cell Sci.

Naj X, Linder S. (2015)
ER-coordinated activities of Rab22a and Rab5a drive endosomal compaction and intracellular processing of Borrelia burgdorferi by macrophages.
Cell Reports 2015 Sep;12, 1-15
UKE „paper of the month“ Sep 2015

Lin YN, Bhuwania R, Gromova K, Failla AV, Lange T, Riecken K, Linder S, Kneussel M, Izbicki JR, Windhorst S. (2015)
Drosophila homologue of Diaphanous 1 (DIAPH1) controls the metastatic potential of colon cancer cells by regulating microtubule-dependent adhesion.
Oncotarget. 2015 Jul 30;6(21):18577-89
UKE „paper of the month“ July 2015

Bhuwania R, Castro-Castro A, Linder S. (2014)
Microtubule acetylation regulates dynamics of KIF1C-powered vesicles and contact of microtubule plus ends with podosomes.
Eur. J Cell Biol. 2014 Okt;93(10-12):424-37

Hoffmann AK, Naj X, Linder S. (2014)
Daam1 is a regulator of filopodia formation and phagocytic uptake of Borrelia burgdorferi by primary human macrophages.
FASEB J. 2014 Jul;28(7):3075-3089

Rehm K, Panzer L, van Vliet V, Genot E, Linder S. (2013)
Drebrin preserves endothelial integrity by stabilizing nectin at adherens junctions.
J Cell Sci. 2013 Aug 15;126:3756-3769.
highlighted in the „In this Issue“ section of J. Cell Sci.
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Wiesner C, El Azzouzi K, Linder S. (2013)
A specific subset of RabGTPases controls cell surface exposure of MT1-MMP, extracellular matrix degradation and 3D invasion of macrophages.
J Cell Sci. 2013 Jul 1;126(Pt 13):2820-33.
highlighted in the „In this Issue“ section of J. Cell Sci.

Naj X, Hoffmann AK, Himmel M, Linder S. (2013)
The formins FMNL1 and mDia1 regulate coiling phagocytosis of Borrelia burgdorferi by primary human macrophages.
Infect Immun. 2013 May;81(5):1683-95. Epub 2013 Mar 4.

Ziemann A, Hess S, Bhuwania R, Linder S, Kloppenburg P, Noegel AA, Clemen CS. (2013)
CRN2 enhances the invasiveness of glioblastoma cells.
Neuro Oncol. 2013 May;15(5):548-61.

Cervero P, Himmel M, Krüger M, Linder S. (2012)
Proteomic analysis of podosome fractions from macrophages reveals similarities to spreading initiation centres.
Eur J Cell Biol. 2012 Nov;91(11-12):908-22. Epub 2012 Jun 20.

Stölting M, Wiesner C, van Vliet V, Butt E, Pavenstädt H, Linder S, Kremerskothen J. (2012)
Lasp-1 regulates podosome function.
PLoS One. 2012;7(4):e35340. Epub 2012 Apr 13.

Bhuwania R, Cornfine S, Fang Z, Krüger M, Luna EJ, Linder S.(2012)
Supervillin couples myosin-dependent contractility to podosomes and enables their turnover.
J Cell Sci. 2012 May 1;125(Pt 9):2300-14. Epub 2012 Feb 17.

Praekelt U, Kopp PM, Rehm K, Linder S, Bate N, Patel B, Debrand E, Manso AM, Ross RS, Conti F, Zhang MZ, Harris RC, Zent R, Critchley DR, Monkley SJ.(2012)
New isoform-specific monoclonal antibodies reveal different sub-cellular localisations for talin1 and talin2.
Eur J Cell Biol. 2012 Mar;91(3):180-91. Epub 2012 Feb 3.

Xavier CP, Rastetter RH, Blömacher M, Stumpf M, Himmel M, Morgan RO, Fernandez MP, Wang C, Osman A, Miyata Y, Gjerset RA, Eichinger L, Hofmann A, Linder S, Noegel AA, Clemen CS.(2012)
Phosphorylation of CRN2 by CK2 regulates F-actin and Arp2/3 interaction and inhibits cell migration.
Sci Rep. 2012;2:241. Epub 2012 Jan 31.

Cornfine S, Himmel M, Kopp P, El Azzouzi K, Wiesner C, Krüger M, Rudel T, Linder S.(2011)
The kinesin KIF9 and reggie/flotillin proteins regulate matrix degradation by macrophage podosomes.
Mol Biol Cell. 2011 Jan;22(2):202-15. Epub 2010 Nov 30.

Kremerskothen J, Stölting M, Wiesner C, Korb-Pap A, van Vliet V, Linder S, Huber TB, Rottiers P, Reuzeau E, Genot E, Pavenstädt H.(2011)
Zona occludens proteins modulate podosome formation and function.
FASEB J. 2011 Feb;25(2):505-14. Epub 2010 Oct 7.

Wiesner C, Faix J, Himmel M, Bentzien F, Linder S.(2010)
KIF5B and KIF3A/KIF3B kinesins drive MT1-MMP surface exposure, CD44 shedding and extracellular matrix degradation in primary macrophages.
Blood. 2010 Sep 2;116(9):1559-69. Epub 2010 May 26.

Xavier CP, Rastetter RH, Stumpf M, Rosentreter A, Müller R, Reimann J, Cornfine S, Linder S, van Vliet V, Hofmann A, Morgan RO, Fernandez MP, Schröder R, Noegel AA, Clemen CS.(2009)
Structural and functional diversity of novel coronin 1C (CRN2) isoforms in muscle.
J Mol Biol. 2009 Oct 23;393(2):287-99. Epub 2009 Aug 3.

Weinmeister P, Lukowski R, Linder S, Traidl-Hoffmann C, Hofmann F, Feil R.(2008)
Cyclic guanosine monophosphate-dependent protein kinase I promotes adhesion of primary vascular smooth muscle cells.
Mol Biol Cell. 2008 Oct;19(10):4434-41. Epub 2008 Aug 6.

Reichel CA, Rehberg M, Bihari P, Moser CM, Linder S, Khandoga A, Krombach F.(2008)
Gelatinases mediate neutrophil recruitment in vivo: evidence for stimulus-specificity and a critical role in collagen IV remodeling.
J Leukoc Biol. 2008 Apr;83(4):864-74. Epub 2008 Jan 3.

Thal D, Xavier CP, Rosentreter A, Linder S, Friedrichs B, Waha A, Pietsch T, Stumpf M, Noegel A, Clemen C.(2008)
Expression of coronin-3 (coronin-1C) in diffuse gliomas is related to malignancy.
J Pathol. 2008 Mar;214(4):415-24.

Chellaiah MA, Kuppuswamy D, Lasky L, Linder S.(2007)
Role of Src kinase and PTP-PEST in the regulation of phosphorylation of WASP and resulting osteoclast bone resorption.
J Biol Chem. 2007 Mar 30;282(13):10104-16. Epub 2007 Feb 5.

Trasak C, Zenner G, Vogel A, Yüksekdag G, Rost R, Haase I, Fischer M, Israel L, Imhof A, Linder S, Schleicher M, Aepfelbacher M.(2007)
Yersinia protein kinase YopO is activated by a novel G-actin binding process.
J Biol Chem. 2007 Jan 26;282(4):2268-77. Epub 2006 Nov 22.

Schröder A, Schröder B, Roppenser B, Linder S, Sinha B, Fässler R, Aepfelbacher M.(2006)
Live cell imaging of Staphylococcus aureus induced attachment sites, movements and actin dynamics on the surface of human endothelial cells.
Mol. Biol. Cell. 17:5198-5210. Epub 2006 Oct 4.

Gringel A, Walz D, Rosenberger G, Minden A, Kutsche K, Kopp P, Linder S. (2006)
PAK4 and alphaPIX determine podosome size and number in macrophages through localized actin regulation.
J. Cell. Physiol. 209:568-579

Ussar S, Wang HV, Linder S, Fässler R, Moser M. (2006)
The kindlins: subcellular localization and expression during murine development.
Exp. Cell Res. 312(16):3142-3151. Epub 2006 Jun 29.

Kopp P, Lammers R, Aepfelbacher M, Woehlke G, Rudel T, Machuy N, Steffen W, Linder S.(2006)
The kinesin KIF1C and microtubule plus ends regulate podosome dynamics in macrophages.
Mol. Biol. Cell 17(6):2811-2823. Epub 2006 Mar 22.

Odenbreit S, Linder S, Gebert-Vogl B, Rieder G, Moran AP, Haas R.(2006)
Interleukin-6 induction by Helicobacter pylori in human macrophages is dependent on phagocytosis.
Helicobacter 11(3):196-207

Osiak AE, Zenner G, Linder S.(2005)
Subconfluent endothelial cells form podosomes downstream of cytokine and RhoGTPase signaling.
Exp. Cell Res. 307(2):342-353

Hristov M, Erl W, Linder S, Weber PC.(2004)
Apoptotic bodies from endothelial cells enhance the number and initiate the differentiation of human endothelial progenitor cells in vitro.
Blood 104:2761-2766. Epub 2004 Jul 8.
(reviewed in: Sane, D.C. (2004). The endothelial life insurance plan. Blood , 104 (9): 2615-2616)

Majstoravich S, Zhang J, Nicholson-Dykstra S, Linder S, Friedrich W, Siminovitch KA, Higgs HN.(2004)
Lymphocyte microvilli are dynamic, actin-dependent structures that do not require Wiskott-Aldrich Syndrome protein (WASp) for their morphology.
Blood 104:1396-1403. Epub 2004 May 6.
(reviewed in: Bartels, J.R. (2004). The core of the lymphocyte microvilli-WASp issue. Blood , 104 (5): 1232-1233)

Brühl H, Cohen CD, Linder S, Kretzler M, Schlöndorff D, Mack M.(2003)
Post-translational and cell type-specific regulation of CXCR4 expression by cytokines.
Eur. J. Immunol., 33:3028-3037

Essler M, Linder S, Schell B, Hüfner K, Wiedemann A, Randhahn K, Staddon JM, Aepfelbacher M. (2003)
Cytotoxic necrotizing factor 1 of Escherichia coli stimulates Rho/Rho-kinase-dependent myosin light-chain phosphorylation without inactivating myosin light-chain phosphatase in endothelial cells.
Infect. Immun., 71:5188-5193

Linder S, Wintergerst U, Bender-Götze C, Schwarz K, Pannicke U, Aepfelbacher M.(2003)
Macrophages from patients with X-linked thrombocytopenia (XLT) display an attenuated Wiskott-Aldrich syndrome phenotype.
Immunol. Cell Biol., 81:130-136

Essler M, Retzer M, Ilchmann H, Linder S, Weber PC.(2002)
Sphingosine-1 phosphate dynamically regulates myosin light chain phosphatase-activity in human endothelial cells.
Cell. Signall., 14:607-613

Hüfner K, Schell B, Aepfelbacher M, Linder S.(2002)
The acidic regions of WASp and N-WASP can synergize with CDC42Hs and Rac1 to induce filopodia and lamellipodia.
FEBS Lett., 514:168-174

Linder S, Pinkowski W, Aepfelbacher M.(2002)
Adhesion, cytoskeletal architecture and activation status of primary human macrophages on a diamond-like carbon-coated surface.
Biomaterials, 23:767-773

Wiedemann A, Linder S, Grassl G, Albert M, Autenrieth I, Aepfelbacher M.(2001)
Yersinia enterocolitica invasin triggers formation of macrophage phagocytic cups via b1-integrins, CDC42Hs and WASp.
Cell. Microbiol., 3:693-702

Hüfner K, Higgs HN, Pollard TD, Jacobi C, Aepfelbacher M, Linder S.(2001)
The verprolin-like central (VC) region of Wiskott-Aldrich syndrome protein induces Arp2/3 complex-dependent actin nucleation.
J. Biol. Chem., 276:5761-35767. Epub 2001 Jul 17.

Czech A, Yamaguchi T, Bader L, Linder S, Kaminski K, Sugai M, Aepfelbacher M.(2001)
Distribution of Rho-inactivating Edin-toxins in clinical Staphylococcus aureus isolates.
J. Infect. Dis., 184:785-788. Epub 2001 Aug 15.

Linder S, Heimerl C, Fingerle V, Aepfelbacher M, Wilske B.(2001)
Coiling phagocytosis of Borrelia burgdorferi by primary human macrophages is controlled by CDC42Hs and Rac1 and involves recruitment of Wiskott-Aldrich syndrome protein and Arp2/3 complex.
Infect. & Immun., 69:1739-1746

Linder S, Hüfner K, Wintergerst U, Aepfelbacher M.(2000)
Microtubule-dependent formation of podosomal adhesion structures in primary human macrophages.
J. Cell Sci., 113:4165-4176

Stender S, Friebel A, Linder S, Rohde M, Mirold S, Hardt WD.(2000)
Identification of SopE2 from S. typhimurium, a conserved G-nucleotide exchange factor for RhoGTPases of the host cell.
Mol. Microbiol., 36:1206-1221

Linder S, Higgs H, Hüfner K, Schwarz K, Pannicke U, Aepfelbacher M.(2000)
The polarization defect of Wiskott-Aldrich syndrome macrophages is linked to dislocalisation of the Arp2/3 complex.
J. Immunol., 165:221-225

Linder S, Nelson D, Weiss M, Aepfelbacher M.(1999)
Wiskott-Aldrich syndrome protein regulates podosomes in primary human macrophages
Proc. Natl. Acad. Sci. USA, 96 (17):9648-9653
(reviewed in: Novak, K. (1999). Mutant WASp stops cells in their tracks. Nature Med., 5 (10): 1128)